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TWIST Monoclonal Antibody, Active Motif™
SDP

Catalog No. 501993139
Encompass
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50-199-3139 100 μg
50-199-3140 10 μg
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Catalog No. 50-199-3139 Supplier Active Motif Supplier No. 61097
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Description

Mouse Monoclonal Antibody

TWIST1 acts as a transcriptional regulator. It inhibits myogensis by sequestering E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. TWIST1 also represses proinflammatory cytokines such as TNFA and IL1B. TWIST also regulates cranial suture patterning and fusion and gene expression differentially depending on dimer composition. Mutations in the gene are implicated in Saethre-Chotzen syndrome, a disease characterized by coronal synostosis, brachycephaly, low front hairline, facial asymmetry, hypertelorism, broad halluces, and clinodactyly.

Specifications

Antigen TWIST
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
Classification Monoclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene TWIST1
Gene Accession No. P26687, Q15672
Gene Alias AA960487; ACS3; B-HLH DNA binding protein; BHLHA38; BOS_4079; BPES2; BPES3; charlie chaplin; Class A basic helix-loop-helix protein 38; CRS; CRS1; CSO; H-twist; M-twist; p ACS3; Pde; pdt; Pluridigite; polydactyly EMS; SCS; Ska; Skam10Jus; Ska10; Twist; twist basic helix-loop-helix transcription factor 1; twist family bHLH transcription factor 1; twist gene homolog 1; twist homolog 1; twist homolog 1 (Drosophila); TWIST homolog of drosophila; TWIST1; Twist-related protein 1
Gene Symbols TWIST1
Host Species Mouse
Immunogen This TWIST antibody was raised against a recombinant protein corresponding to full-length mouse TWIST.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22160, 7291
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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