TWIST Monoclonal Antibody, Active Motif™

Mouse Monoclonal Antibody

Supplier:  Active Motif 61098

Catalog No. 50-199-3140

Description

TWIST1 acts as a transcriptional regulator. It inhibits myogensis by sequestering E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. TWIST1 also represses proinflammatory cytokines such as TNFA and IL1B. TWIST also regulates cranial suture patterning and fusion and gene expression differentially depending on dimer composition. Mutations in the gene are implicated in Saethre-Chotzen syndrome, a disease characterized by coronal synostosis, brachycephaly, low front hairline, facial asymmetry, hypertelorism, broad halluces, and clinodactyly.

Specifications

• Antigen: TWIST
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: TWIST1
• Gene Alias: AA960487; ACS3; B-HLH DNA binding protein; BHLHA38; BOS_4079; BPES2; BPES3; charlie chaplin; Class A basic helix-loop-helix protein 38; CRS; CRS1; CSO; H-twist; M-twist; p ACS3; Pde; pdt; Pluridigite; polydactyly EMS; SCS; Ska; Ska^m10Jus; Ska10; Twist; twist basic helix-loop-helix transcription factor 1; twist family bHLH transcription factor 1; twist gene homolog 1; twist homolog 1; twist homolog 1 (Drosophila); TWIST homolog of drosophila; TWIST1; Twist-related protein 1
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 22160, 7291
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
• Gene Accession No.: P26687, Q15672
• Gene Symbols: TWIST1
• Immunogen: This TWIST antibody was raised against a recombinant protein corresponding to full-length mouse TWIST.
• Quantity: 10 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1