Invitrogen™ TWIST1 Monoclonal Antibody (2F8E7)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA517195

Catalog No. PIMA517195

Description

MA5-17195 targets TWIST1 in indirect ELISA, WB applications and shows reactivity with Human samples. The MA5-17195 immunogen is purified recombinant fragment of human TWIST1 (amino acids: 9-74) expressed in E. Coli. MA5-17195 detects TWIST1 which has a predicted molecular weight of approximately 21kDa.

TWIST1 acts as a transcriptional regulator. It inhibits myogensis by sequestering E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. TWIST1 also represses proinflammatory cytokines such as TNFA and IL1B. TWIST also regulates cranial suture patterning and fusion and gene expression differentially depending on dimer composition. Mutations in the gene are implicated in Saethre-Chotzen syndrome, a disease characterized by coronal synostosis, brachycephaly, low front hairline, facial asymmetry, hypertelorism, broad halluces, and clinodactyly.

Specifications

• Antigen: TWIST1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: Q15672
• Gene Symbols: TWIST1
• Immunogen: Purified recombinant fragment of human TWIST1 (amino acids: 9-74) expressed in E. Coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: ELISA, Western Blot, Immunocytochemistry
• Clone: 2F8E7
• Conjugate: Unconjugated
• Gene: TWIST1
• Gene Alias: AA960487; ACS3; B-HLH DNA binding protein; bHLHa38; BPES2; BPES3; charlie chaplin; class A basic helix-loop-helix protein 38; CRS; CRS1; CSO; H-twist; M-twist; p ACS3; Pde; pdt; Pluridigite; polydactyly EMS; SCS; Ska>m10Jus>; Ska>sup>m10Jus>/sup>; Ska10; Twist; twist basic helix-loop-helix transcription factor 1; twist family bHLH transcription factor 1; twist gene homolog 1; twist homolog 1; TWIST homolog of drosophila; Twist1; twist-related protein 1
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 7291
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid