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Invitrogen™ TWIST1 Monoclonal Antibody (2F8E7)
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Catalog No. PIMA517195
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100 μg
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Catalog No. Quantity
PIMA517195 100 μg
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Catalog No. PIMA517195 Supplier Invitrogen™ Supplier No. MA517195
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Description

Mouse Monoclonal Antibody

MA5-17195 targets TWIST1 in indirect ELISA, WB applications and shows reactivity with Human samples. The MA5-17195 immunogen is purified recombinant fragment of human TWIST1 (amino acids: 9-74) expressed in E. Coli. MA5-17195 detects TWIST1 which has a predicted molecular weight of approximately 21kDa.

TWIST1 acts as a transcriptional regulator. It inhibits myogensis by sequestering E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. TWIST1 also represses proinflammatory cytokines such as TNFA and IL1B. TWIST also regulates cranial suture patterning and fusion and gene expression differentially depending on dimer composition. Mutations in the gene are implicated in Saethre-Chotzen syndrome, a disease characterized by coronal synostosis, brachycephaly, low front hairline, facial asymmetry, hypertelorism, broad halluces, and clinodactyly.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TWIST1
Applications ELISA, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 2F8E7
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene TWIST1
Gene Accession No. Q15672
Gene Alias AA960487; ACS3; B-HLH DNA binding protein; bHLHa38; BPES2; BPES3; charlie chaplin; class A basic helix-loop-helix protein 38; CRS; CRS1; CSO; H-twist; M-twist; p ACS3; Pde; pdt; Pluridigite; polydactyly EMS; SCS; Ska>m10Jus>; Ska>sup>m10Jus>/sup>; Ska10; Twist; twist basic helix-loop-helix transcription factor 1; twist family bHLH transcription factor 1; twist gene homolog 1; twist homolog 1; TWIST homolog of drosophila; Twist1; twist-related protein 1
Gene Symbols TWIST1
Host Species Mouse
Immunogen Purified recombinant fragment of human TWIST1 (amino acids: 9-74) expressed in E. Coli.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7291
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b
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