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Invitrogen™ TWIST1 Polyclonal Antibody
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Catalog No. PIPA547824
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100 μg
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PIPA547824 100 μg
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Catalog No. PIPA547824 Supplier Invitrogen™ Supplier No. PA547824
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Description

Sheep Polyclonal Antibody

In direct ELISAs, less than 16% cross-reactivity with recombinant human Twist-2 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

TWIST1 acts as a transcriptional regulator. It inhibits myogensis by sequestering E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. TWIST1 also represses proinflammatory cytokines such as TNFA and IL1B. TWIST also regulates cranial suture patterning and fusion and gene expression differentially depending on dimer composition. Mutations in the gene are implicated in Saethre-Chotzen syndrome, a disease characterized by coronal synostosis, brachycephaly, low front hairline, facial asymmetry, hypertelorism, broad halluces, and clinodactyly.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TWIST1
Applications Flow Cytometry, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene TWIST1
Gene Accession No. Q15672
Gene Alias AA960487; ACS3; B-HLH DNA binding protein; bHLHa38; BPES2; BPES3; charlie chaplin; class A basic helix-loop-helix protein 38; CRS; CRS1; CSO; H-twist; M-twist; p ACS3; Pde; pdt; Pluridigite; polydactyly EMS; SCS; Ska>m10Jus>; Ska>sup>m10Jus>/sup>; Ska10; Twist; twist basic helix-loop-helix transcription factor 1; twist family bHLH transcription factor 1; twist gene homolog 1; twist homolog 1; TWIST homolog of drosophila; Twist1; twist-related protein 1
Gene Symbols TWIST1
Host Species Sheep
Immunogen E. coli-derived recombinant human Twist-1 Met1-His202.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7291
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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Safety and Handling

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