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Invitrogen™ TWIST1 Polyclonal Antibody
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Catalog No. PA549688
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100 μL
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PA549688 100 μL
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Catalog No. PA549688 Supplier Invitrogen™ Supplier No. PA549688
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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total TWIST1 protein.

TWIST1 acts as a transcriptional regulator. It inhibits myogensis by sequestering E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. TWIST1 also represses proinflammatory cytokines such as TNFA and IL1B. TWIST also regulates cranial suture patterning and fusion and gene expression differentially depending on dimer composition. Mutations in the gene are implicated in Saethre-Chotzen syndrome, a disease characterized by coronal synostosis, brachycephaly, low front hairline, facial asymmetry, hypertelorism, broad halluces, and clinodactyly.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TWIST1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.85 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene TWIST1
Gene Accession No. P26687, Q15672
Gene Alias AA960487; ACS3; B-HLH DNA binding protein; bHLHa38; BPES2; BPES3; charlie chaplin; class A basic helix-loop-helix protein 38; CRS; CRS1; CSO; H-twist; M-twist; p ACS3; Pde; pdt; Pluridigite; polydactyly EMS; SCS; Ska>m10Jus>; Ska>sup>m10Jus>/sup>; Ska10; Twist; twist basic helix-loop-helix transcription factor 1; twist family bHLH transcription factor 1; twist gene homolog 1; twist homolog 1; TWIST homolog of drosophila; Twist1; twist-related protein 1
Gene Symbols TWIST1
Host Species Rabbit
Immunogen Recombinant fusion protein of Twist (aa 1-100).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22160, 7291, 85489
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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