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Invitrogen™ Twist1/Twist2 Polyclonal Antibody
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Catalog No. PIPA5143850
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100 μg
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PIPA5143850 100 μg
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Catalog No. PIPA5143850 Supplier Invitrogen™ Supplier No. PA5143850
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Description

Rabbit Polyclonal Antibody

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: rat brain tissue, rat ovary tissue, mouse brain tissue, mouse ovary tissue. IHC: human penis squamous cell carcinoma tissue, human lung squamous cell carcinoma tissue, human lung cancer tissue, mouse brain tissue, rat brain tissue. Flow: THP-1 cell, RAW2647 cell, RH35 cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Twist1/Twist2 encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. This protein may also regulate neural tube closure, limb development and brown fat metabolism. Twist1/Twist2 is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis. Mutations in this gene cause Saethre-Chotzen syndrome in human patients, which is characterized by craniosynostosis, ptosis and hypertelorism.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Twist1/Twist2
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 4mg trehalose and no preservative
Gene TWIST1
Gene Accession No. P26687, P97831, Q15672, Q8WVJ9, Q9D030
Gene Alias AA960487; ACS3; AMS; BBRSAY; B-HLH DNA binding protein; bHLHa38; BHLHA39; BPES2; BPES3; charlie chaplin; class A basic helix-loop-helix protein 38; Class A basic helix-loop-helix protein 39; CRS; CRS1; CSO; dermis expressed 1; dermis-expressed protein 1; DERMO1; Dermo-1; dermo-1 protein; FFDD3; H-twist; MGC117334; M-Twist; Pde; pdt; Pluridigite; polydactyly EMS; SCS; SETLSS; Ska>m10Jus>; Ska>sup>m10Jus>/sup>; Ska10; Twist; twist basic helix-loop-helix transcription factor 1; twist basic helix-loop-helix transcription factor 2; twist family bHLH transcription factor 1; twist family bHLH transcription factor 2; twist gene homolog 1; twist homolog 1; twist homolog 2; TWIST homolog of drosophila; Twist1; Twist2; twist-related bHLH protein Dermo1; twist-related protein 1; Twist-related protein 2
Gene Symbols TWIST1, TWIST2
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence of human TWIST1/2 (KIIPTLPSDKLSKIQTLKLAARY).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 117581, 13345, 22160, 59327, 7291, 85489
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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