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Invitrogen™ Twist1/Twist2 Polyclonal Antibody
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Catalog No. PIPA578211
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100 μL
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PIPA578211 100 μL
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Catalog No. PIPA578211 Supplier Invitrogen™ Supplier No. PA578211
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Description

Rabbit Polyclonal Antibody

Positive Control: Raji, THP-1, HL-60, TWIST1 transfected 293T lysates, human TWIST1-transfected 293T, Jurkat, OECM1, CL1-5, Toledo, SU-DHL-5, HT, DB, RL95-2, MDA-MB-231 Predicted Reactivity: Japanese Medaka (95%), Xenopus laevis (97%), Chicken (100%), Chimpanzee (100%), Bovine (100%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Twist1/Twist2 encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. This protein may also regulate neural tube closure, limb development and brown fat metabolism. Twist1/Twist2 is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis. Mutations in this gene cause Saethre-Chotzen syndrome in human patients, which is characterized by craniosynostosis, ptosis and hypertelorism.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Twist1/Twist2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.67 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene TWIST1
Gene Accession No. P26687, P97831, Q15672, Q8WVJ9, Q9D030
Gene Alias AA960487; ACS3; AMS; BBRSAY; B-HLH DNA binding protein; bHLHa38; BHLHA39; BPES2; BPES3; charlie chaplin; class A basic helix-loop-helix protein 38; Class A basic helix-loop-helix protein 39; CRS; CRS1; CSO; dermis expressed 1; dermis-expressed protein 1; DERMO1; Dermo-1; dermo-1 protein; FFDD3; H-twist; MGC117334; M-Twist; Pde; pdt; Pluridigite; polydactyly EMS; SCS; SETLSS; Ska>m10Jus>; Ska>sup>m10Jus>/sup>; Ska10; Twist; twist basic helix-loop-helix transcription factor 1; twist basic helix-loop-helix transcription factor 2; twist family bHLH transcription factor 1; twist family bHLH transcription factor 2; twist gene homolog 1; twist homolog 1; twist homolog 2; TWIST homolog of drosophila; Twist1; Twist2; twist-related bHLH protein Dermo1; twist-related protein 1; Twist-related protein 2
Gene Symbols TWIST1, TWIST2
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human Twist1/2. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 117581, 13345, 22160, 59327, 7291, 85489
Target Species Human, Mouse, Rat, Drosophila
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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