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Tocris Bioscience™ TWS 119
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Catalog No. 740510
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Quantity:
10 mg
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This item is not returnable. View return policy

Description

Potent GSK3 inhibitor; induces neuronal and CD8(+) T cell differentiation

TWS 119 is a potent inhibitor of glycogen synthase kinase-3β (IC50 = 30 nM). TWS 119 inhibits both GSK3α and GSK3β in vitro (IC50 = 88 nM and 410 nM, respectively). TWS 119 induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells at 400 nM. TWS 119 enhances the proliferation and survival of γδ T-cells, and induces differentiation of CD8+ T cells towards a stem cell-like memory T cell phenotype at 2.5 μM.

Specifications

Chemical Name or Material 3-[[6-(3-Aminophenyl)-7 H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
CAS 601514-19-6
Quantity 10 mg
Target GSK-3 Inhibitors
Molecular Formula C18H14N4O2
Purity 0.97
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