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Invitrogen™ TXK Polyclonal Antibody
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Catalog No. PIPA5141990
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100 μg
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PIPA5141990 100 μg
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Catalog No. PIPA5141990 Supplier Invitrogen™ Supplier No. PA5141990
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Description

Goat Polyclonal Antibody

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.

TXK, along with the close relatives BMS, ITK, and BTK, signal downstream of antigen receptors and other types of receptors. All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini. Four alternatively spliced forms of Tec are found to be expressed broadly in cells of hematopoietic lineage and hepatocytes. The Emt gene product associates with CD28 and becomes activated subsequent to CD28 ligation. Btk is necessary for proper B cell development, and mutations in the gene encoding Btk have been associated with families suffering from X-linked agammaglobulinemia, also referred to as Bruton's disease. The Bmx protein shares a high degree of homology with Btk and seems to be expressed at highest levels in the heart. Txk expression is T cell-specific, while expression of the Drosophila Tec homolog, Dsrc28C, is developmentally regulated.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TXK
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene TXK
Gene Accession No. P42681
Gene Alias A130089B16Rik; BTKL; Protein-tyrosine kinase 4; PSCTK5; PTK4; PTK4 protein tyrosine kinase 4; PTK-RL-18; resting lymphocyte kinase; Rlk; TKL; TXK; TXK tyrosine kinase; tyrosine kinase; tyrosine-protein kinase TXK
Gene Symbols TXK
Host Species Goat
Immunogen Peptide with sequence C-ELLRAVTEIAETW.
Purification Method Ammonium Sulfate Precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7294
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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