Invitrogen™ TXK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA514797

Catalog No. PIPA514797

Description

TXK Polyclonal Antibody for Western Blot, IHC (P)

TXK, along with the close relatives BMS, ITK, and BTK, signal downstream of antigen receptors and other types of receptors. All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini. Four alternatively spliced forms of Tec are found to be expressed broadly in cells of hematopoietic lineage and hepatocytes. The Emt gene product associates with CD28 and becomes activated subsequent to CD28 ligation. Btk is necessary for proper B cell development, and mutations in the gene encoding Btk have been associated with families suffering from X-linked agammaglobulinemia, also referred to as Bruton's disease. The Bmx protein shares a high degree of homology with Btk and seems to be expressed at highest levels in the heart. Txk expression is T cell-specific, while expression of the Drosophila Tec homolog, Dsrc28C, is developmentally regulated.

Specifications

• Antigen: TXK
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TXK
• Gene Alias: A130089B16Rik; BTKL; Protein-tyrosine kinase 4; PSCTK5; PTK4; PTK4 protein tyrosine kinase 4; PTK-RL-18; resting lymphocyte kinase; Rlk; TKL; TXK; TXK tyrosine kinase; tyrosine kinase; tyrosine-protein kinase TXK
• Host Species: Rabbit
• Purification Method: Ammonium sulfate precipitation, Size-exclusion - Dialysis
• Regulatory Status: RUO
• Gene ID (Entrez): 7294
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: P42681
• Gene Symbols: TXK
• Immunogen: KLH conjugated synthetic peptide between 22-52 amino acids from the N-terminal region of human TXK.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG