Invitrogen™ Human TXK, GST Tag Recombinant Protein

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Recombinant, Catalytic Domain

TXK, along with the close relatives BMS, ITK, and BTK, signal downstream of antigen receptors and other types of receptors. All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini. Four alternatively spliced forms of Tec are found to be expressed broadly in cells of hematopoietic lineage and hepatocytes. The Emt gene product associates with CD28 and becomes activated subsequent to CD28 ligation. Btk is necessary for proper B cell development, and mutations in the gene encoding Btk have been associated with families suffering from X-linked agammaglobulinemia, also referred to as Bruton's disease. The Bmx protein shares a high degree of homology with Btk and seems to be expressed at highest levels in the heart. Txk expression is T cell-specific, while expression of the Drosophila Tec homolog, Dsrc28C, is developmentally regulated.

Specifications

• Accession Number: P42681
• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50 mM tris with no preservative
• Gene ID (Entrez): 7294
• Molecular Weight (g/mol): 58.5 kDa
• Name: Human TXK, GST Tag
• Quantity: 10 μg
• Gene Alias: A130089B16Rik; BTKL; Protein-tyrosine kinase 4; PSCTK5; PTK4; PTK4 protein tyrosine kinase 4; PTK-RL-18; resting lymphocyte kinase; Rlk; TKL; TXK; TXK tyrosine kinase; tyrosine kinase; tyrosine-protein kinase TXK
• Common Name: TXK
• KinaseFamily: TEC Kinase Family
• Protein Length: 260-527
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: GST-tag
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Assay Entry: Biochemical terbium phospho-specific activity
• Kinase Group: Tyrosine Kinases
• Shipping Condition: Dry Ice
• System Compatibility: LanthaScreen™
• Tag Position: N-Terminal
• Target Entry: TXK
• Target Gene: TXK
• Expression System: Baculovirus
• Protein Family: Kinases & Inhibitors
• Protein Form: Recombinant, Catalytic Domain
• Form: Liquid
• Protein Subtype: Cytoplasmic Tyrosine Kinases
• Research Category: Signal Transduction