MilliporeSigma™ TXNIP, Mouse, Unlabeled, Clone: 3A7.1,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABC605

Catalog No. MABC605MI

Description

Thioredoxin-interacting protein (UniProt Q9H3M7; also known as Thioredoxin-binding protein 2, Vitamin D3 up-regulated protein 1) is encoded by the TXNIP (also known as VDUP1) gene (Gene ID 10628) in human. Thioredoxin interacting protein (TXNIP) binds thioredoxin active cysteine residue and suppresses its antioxidant activity. TXNIP overexpression results in increased cellular ROS level and oxidative cell death, while TXNIP suppression enhances cellular resistance to oxidative injury. TXNIP is also shown to inhibit cellular glucose uptake by downregulating glucose transporter 1 (GLUT1) plasma membrane localization, and TXNIP expression is found to be markedly suppressed in many cancers, making TXNIP a potential anticancer therapeutic target.

Specifications

• Antigen: TXNIP
• Classification: Monoclonal
• Concentration: Please refer to lot specific datasheet.
• Formulation: Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
• Gene Accession No.: Q9H3M7
• Immunogen: GST-tagged recombinant fragment from the N-terminal half of human TXNIP.
• Quantity: 100 μg
• Research Discipline: Apoptosis & Cancer
• Gene ID (Entrez): NP_006463
• Target Species: Human
• Form: Purified

• Applications: Western Blot
• Clone: 3A7.1
• Conjugate: Unconjugated
• Gene: TXNIP, VDUP1
• Host Species: Mouse
• Purification Method: Protein G Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Clone 3A7.1 targets an epitope within the N-terminal half of TXNIP. Cross-reactivity to human and mouse spliced isoform 2 is likely, but has not been confirmed.
• Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
• Isotype: IgG2b κ

For Research Use Only. Not for use in diagnostic procedures.