Invitrogen™ TXNL4B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596584

Catalog No. PIPA596584

Description

Immunogen sequence: MSFLLPKLTS KKEVDQAIKS TAEKVLVLRF GRDEDPVCLQ LDDILSKTSS DLSKMAAIYL VDVDQTAVYT QYFDISYIPS TVFFFNGQHM KVDYGSPDHT KFVGSFKTKQ DFIDLIEVIY RGAMRGKLIV QSPIDPKNIP KYDLLYQDI; Positive Samples: Mouse liver; Cellular Location: Nucleus.

Dim2, also known as TXNL4B (thioredoxin-like 4B), or DLP, is a 149 amino acid nuclear protein that exists as a homodimer and plays an essential role in pre-mRNA splicing. Evolutionarily related and sharing 38% sequence identity with Dim1, Dim2 is required for S/G(2) transition during the cell cycle and is able to bind the PRP6 (U5-102K) subunit of the spliceosome. The gene encoding Dim2 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The rare disorder Rubinstein-Taybi syndrome is associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.

Specifications

• Antigen: TXNL4B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TXNL4B
• Gene Alias: AI595343; D530025J19Rik; Dim1-like protein; DIM2; DLP; RGD1305127; thioredoxin like 4B; thioredoxin-like 4B; thioredoxin-like protein 4B; Txnl4b
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 234723, 54957
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 0.4 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q8BUH1, Q9NX01
• Gene Symbols: TXNL4B
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-149 of human TXNL4B (NP_0603231).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov