TYMS Mouse anti-Human, Clone: OTI1B2, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF801762

Catalog No. 50-166-5720

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Thymidylate Synthase (TS) (EC 2.1.1.45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Specifications

• Antigen: TYMS
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: TYMS
• Gene Alias: HST422, TMS, TS
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7298
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1B2
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P04818
• Gene Symbols: TYMS
• Immunogen: Full length human recombit protein of human TYMS produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a