TYMS Mouse anti-Human, HRP, Clone: 1F5B7, Proteintech

Catalog No.	Quantity
50-173-7244	100 μL

Catalog No. 50-173-7244 Supplier Proteintech Group Inc Supplier No. HRP66725100UL

Description

Mouse Monoclonal Antibody

Thymidylate Synthase (TS) (EC 2.1.1.45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Specifications

• Antigen: TYMS
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 1F5B7
• Concentration: 0.67 mg/mL
• Conjugate: HRP
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene: TYMS
• Gene Accession No.: P04818
• Gene Alias: HsT422, Thymidylate synthase, thymidylate synthetase, TMS, TS, TSase, TYMS
• Gene Symbols: TYMS
• Host Species: Mouse
• Immunogen: TYMS Fusion Protein Ag7027
• Purification Method: Protein G
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7298
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1