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Tyrosinase Antibody (T311 + OCA1/812) - IHC-Prediluted, Novus Biologicals™
SDP

Catalog No. NBP248119 Shop All R&D Systems Products
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NBP248119 7 mL
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Catalog No. NBP248119 Supplier Novus Biologicals Supplier No. NBP248119
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Description

Mouse Monoclonal Antibody

Tyrosinase Monoclonal specifically detects Tyrosinase in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen Tyrosinase
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone T311 + OCA1/812
Conjugate Unconjugated
Dilution Immunohistochemistry-Paraffin
Formulation 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Alias CMM8, EC 1.14.18.1, LB24-AB, Monophenol monooxygenase, OCA1A, OCAIA, SHEP3, SK29-AB, Tumor rejection antigen AB, tyrosinase, tyrosinase (oculocutaneous albinism IA)
Gene Symbols TYR
Host Species Mouse
Immunogen Recombinant tyrosinase protein (Uniprot: P14679 )
Molecular Weight of Antigen 75 kDa
Purification Method Protein A or G purified
Quantity 7 mL
Regulatory Status RUO
Research Discipline Lipid and Metabolism
Primary or Secondary Primary
Gene ID (Entrez) 7299
Test Specificity Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This monoclonal antibody shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this monoclonal antibody shows tyrosinase in melanotic as well as amelanotic variants. This monoclonal antibody is a useful marker for melanocytes and melanomas.
Target Species Human
Content And Storage Store at 4C.
Form Purified
Isotype IgG2a κ
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