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Tyrosinase Antibody (T311 + OCA1/812) - IHC-Prediluted, Novus Biologicals™
SDP

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP248119

Catalog No. NBP248119


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Description

Description

Tyrosinase Monoclonal specifically detects Tyrosinase in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.
Specifications

Specifications

Tyrosinase
Monoclonal
Unconjugated
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
TYR
Recombinant tyrosinase protein (Uniprot: P14679 )
Protein A or G purified
RUO
Primary
Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This monoclonal antibody shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this monoclonal antibody shows tyrosinase in melanotic as well as amelanotic variants. This monoclonal antibody is a useful marker for melanocytes and melanomas.
Store at 4C.
IgG2a κ
Immunohistochemistry (Paraffin)
T311 + OCA1/812
Immunohistochemistry-Paraffin
CMM8, EC 1.14.18.1, LB24-AB, Monophenol monooxygenase, OCA1A, OCAIA, SHEP3, SK29-AB, Tumor rejection antigen AB, tyrosinase, tyrosinase (oculocutaneous albinism IA)
Mouse
75 kDa
7 mL
Lipid and Metabolism
7299
Human
Purified
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