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Tyrosine Hydroxylase Monoclonal Antibody (CL3049), Invitrogen™

Catalog No. PIMA535009
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100 μL
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Catalog No. Quantity
PIMA535009 100 μL
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Catalog No. PIMA535009 Supplier Thermo Scientific Supplier No. MA535009

Description

Mouse Monoclonal Antibody

Immunogen sequence: SESFSDAKDK LRSYASRIQR PFSVKFDPYT LAIDVLDSPQ AVRRSLEGVQ DELDTLAHAL SAIG

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Tyrosine Hydroxylase
Applications Immunohistochemistry
Classification Monoclonal
Clone CL3049
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TH
Gene Accession No. P04177, P07101, P24529
Gene Alias dystonia 14; DYT14; DYT5b; EC 1.14.16.2; HGNC:11782; Th; TH isoform 3; TH isoform a; th1; TH-4; The; TY3H; TYH; TYH antibody; Tyrosine 3-hydroxylase; tyrosine 3-monooxygenase; tyrosine hydroxylase
Gene Symbols TH
Host Species Mouse
Immunogen Recombinant Protein corresonding to Human Tyrosine Hydroxylase
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21823, 25085, 7054
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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