Tyrosine Hydroxylase Monoclonal Antibody (TH-16), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA532984

Catalog No. PIMA532984

Description

Reconstitute with 1 mL of PBS buffer to yield a concentration of 100 μg/mL.

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.

Specifications

• Antigen: Tyrosine Hydroxylase
• Classification: Monoclonal
• Concentration: 100 μg/mL
• Formulation: ascites diluted in 1.2% sodium acetate with 2MG BSA and 0.01MG sodium azide
• Gene Accession No.: P04177, P07101, P24529
• Gene Symbols: TH
• Immunogen: Rat tyrosine hydroxylase (TH).
• Regulatory Status: RUO
• Gene ID (Entrez): 100009362, 21823, 25085, 7054
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Lyophilized

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
• Clone: TH-16
• Conjugate: Unconjugated
• Gene: TH
• Gene Alias: dystonia 14, DYT14, DYT5b, EC 1.14.16.2, HGNC:11782, Th, TH isoform 3, TH isoform a, th1, TH-4, The, TY3H, TYH, TYH antibody, Tyrosine 3-hydroxylase, tyrosine 3-monooxygenase, tyrosine hydroxylase
• Host Species: Mouse
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rabbit, Rat
• Product Type: Antibody
• Isotype: IgG1