Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

TRMT12 Mouse anti-Human, Clone: OTI1C9, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527176

Catalog No. PIMA527176


Add to cart

Description

Description

TYW2, also known as TRM12, is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW2 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW2 was found to be amplified in 7 of 8 breast cancers cell lines analyzed, and qPCR analysis of 30 breast tumors showed overexpression of TYW2 mRNA of over 2-fold in 26, suggesting that TYW2 may play a role in breast cancer.
Specifications

Specifications

TRMT12
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q53H54
TRM12, TYW2; alpha-amino-alpha-carboxypropyl transferase TYW2; homolog of yeast tRNA methyltransferase; tRNA methyltranferase 12 homolog; tRNA wybutosine-synthesizing protein 2 homolog; tRNA-yW synthesizing protein 2; tRNA-yW-synthesizing protein 2
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
55039
Immunohistochemistry (Paraffin), Western Blot
OTI1C9
Unconjugated
TRMT12
Liquid
TRMT12
Full length human recombit protein of TRMT12 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit