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  6. Thermo Scientific Chemicals U-18666A, 95%

Thermo Scientific Chemicals U-18666A, 95%

Catalog No. AAJ67389MA
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Description

Impaired trafficking of cholesterol to or from the endoplasmic reticulum (ER) has been implicated in many disease states including Neimann-Pick disease type C (NPC), Alzheimers disease and atherosclerosis. U-18666A is a cell permeable drug that inhibits cholesterol trafficking. It inhibits cholesterol transport from late endosomes/lysosomes to the endoplasmic reticulum (ER), but not cholesterol transport to the plasma membrane as demonstrated in many cell types including macrophages, primary cortical neurons and primary fibroblasts. In macrophages, micromolar concentrations of U-18666A inhibit multiple pathways of cholesterol trafficking from late endosomes, whereas nanomolar concentrations impair cholesterol trafficking to the ER, a response similar to that found in NPC. U-18666A inhibits oxidosqualene cyclase at high (>0.5 mM) concentrations and oral doses (10 mg/kg) induces cataracts in rats.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 3039-71-2
Molecular Formula C25H41NO2.HCl, C25H42ClNO2
Synonym 3β-[2-(Diethylamino)ethoxy]androstenone hydrochloride

Specifications

Quantity 10 mg
Description White to off-white
Content And Storage 2°C to 8°C
Formula Weight 424.06
Melting Point 195°C to 196.5°C
Solubility Soluble in water at 10mg/ml
Product Type U-18666A, 95%
Form Solid
InChI Key ICPRVJHNLABCSA-UHFFFAOYNA-N
SMILES [H+].[Cl-].CCN(CC)CCOC1CCC2=CCC3C4CCC(=O)C4(C)CCC3C2(C)C1
IUPAC Name hydrogen 8-[2-(diethylamino)ethoxy]-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-one chloride
Molecular Weight (g/mol) 424.07
Assay 95%
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Safety and Handling

Recommended Storage Keep cold
SDS

RUO – Research Use Only

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