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U0126, Tocris Bioscience™ Available on GSA/VA Contract for Federal Government customers only.

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Quantity:
5mg
25mg
109511-58-2
C18H16N6S2
380.488
DVEXZJFMOKTQEZ-JYFOCSDGSA-N
1,4-diamino-2,3-dicyano-1,4-bis o-aminophenylmercapto butadiene,unii-8027p94hll,2z,3z-bis amino 2-aminophenyl sulfanyl methylidene butanedinitrile,2z,3z-bis amino 2-aminophenyl sulfanyl methylidene butanedinitrile,succinonitrile, bis amino o-aminophenylthio methylene,butanedinitrile, bis amino 2-aminophenyl thio methylene,2z,3z-bis amino 2-aminophenyl sulfanyl methylene succinonitrile,2z,3z-2,3-bis amino-2-aminophenyl sulfanyl-methylene butanedinitrile,biomolki_000002,biomolki2_000012
3006531
CHEBI:64208
(2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile
C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N
109511-58-2
C18H16N6S2
380.488
DVEXZJFMOKTQEZ-JYFOCSDGSA-N
1,4-diamino-2,3-dicyano-1,4-bis o-aminophenylmercapto butadiene,unii-8027p94hll,2z,3z-bis amino 2-aminophenyl sulfanyl methylidene butanedinitrile,2z,3z-bis amino 2-aminophenyl sulfanyl methylidene butanedinitrile,succinonitrile, bis amino o-aminophenylthio methylene,butanedinitrile, bis amino 2-aminophenyl thio methylene,2z,3z-bis amino 2-aminophenyl sulfanyl methylene succinonitrile,2z,3z-2,3-bis amino-2-aminophenyl sulfanyl-methylene butanedinitrile,biomolki_000002,biomolki2_000012
3006531
CHEBI:64208
(2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile
C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N

Potent, selective inhibitor of MEK1 and 2

Potent and selective non-competitive inhibitor of MAP kinase kinase. Inhibits MEK-1 and MEK-2 (IC 50 values of 0.07 and 0.06 μM respectively) with little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4. Brain penetrant. Helps maintain human pluripotent stem cells in undifferentiated state. Available as part of the MAPK Cascade Inhibitor Tocriset and MAPK Inhibitor Tocriset . Negative Control also available.

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Quantity 25mg
Formula Weight 380.48
Percent Purity >98%
Chemical Name or Material U0126

Recommended Storage : Desiccate at +4°C