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Invitrogen™ UAP1L1 Polyclonal Antibody
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Catalog No. PIPA560688
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100 μL
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PIPA560688 100 μL
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Catalog No. PIPA560688 Supplier Invitrogen™ Supplier No. PA560688
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SPNWTLDPEP RCRLWSEPRL PAGPGVLAAG SPRLPCRYVM TSEFTLGPTA EFFREHNFFH LDPANVVMFE QRLLPAVTFD GKVILER Highest antigen sequence identity to the following orthologs: Mouse - 46%, Rat - 47%.

UAP1 is a 56KDa isoform which catalyzes the final step of UDP-N-acetylglucosamine (UDP-GlcNAc) biosynthesis from fructose-6-phosphate. UDP-GlcNAc, the activated form of GlcNAc moiety is used as a key precursor in N-linked glycosylation and the glycosylphosphatidylinositol (GPI)-anchor of cellular proteins. Crystallization studies revealed UAP1 is composed of a large central core flanked by two smaller extra domains. The central main domain displays a alpha/beta structure resembling the Rossmann fold. Northern Blot analysis detected abundant expression of UAP1 in testis and sperm with a low expression in placenta, muscle and liver. It is implicated in antibody-mediated infertility in males.
TRUSTED_SUSTAINABILITY

Specifications

Antigen UAP1L1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene UAP1L1
Gene Accession No. Q3KQV9
Gene Alias 5730445F03Rik; UAP1; uap1l1; UDP-N-acetylglucosamine pyrophosphorylase 1 like 1; UDP-N-acetylglucosamine pyrophosphorylase 1, like 1; UDP-N-acetylhexosamine pyrophosphorylase-like protein 1; UDP-N-acteylglucosamine pyrophosphorylase 1, like 1; UDP-N-acteylglucosamine pyrophosphorylase 1-like 1; zgc:56509
Gene Symbols UAP1L1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human UAP1L1. Recombinant protein control fragment (Product #RP-93117).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 91373
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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