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Invitrogen™ UAP1L1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA569578

Catalog No. PIPA569578


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Description

Description

This target displays homology in the following species: Dog: 86%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 83%.

UAP1 is a 56KDa isoform which catalyzes the final step of UDP-N-acetylglucosamine (UDP-GlcNAc) biosynthesis from fructose-6-phosphate. UDP-GlcNAc, the activated form of GlcNAc moiety is used as a key precursor in N-linked glycosylation and the glycosylphosphatidylinositol (GPI)-anchor of cellular proteins. Crystallization studies revealed UAP1 is composed of a large central core flanked by two smaller extra domains. The central main domain displays a alpha/beta structure resembling the Rossmann fold. Northern Blot analysis detected abundant expression of UAP1 in testis and sperm with a low expression in placenta, muscle and liver. It is implicated in antibody-mediated infertility in males.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

UAP1L1
Polyclonal
Unconjugated
UAP1L1
5730445F03Rik; UAP1; uap1l1; UDP-N-acetylglucosamine pyrophosphorylase 1 like 1; UDP-N-acetylglucosamine pyrophosphorylase 1, like 1; UDP-N-acetylhexosamine pyrophosphorylase-like protein 1; UDP-N-acteylglucosamine pyrophosphorylase 1, like 1; UDP-N-acteylglucosamine pyrophosphorylase 1-like 1; zgc:56509
Rabbit
Affinity chromatography
RUO
227620
-20°C, Avoid Freeze/Thaw Cycles
Liquid
Western Blot
0.5 mg/mL
PBS with 2% sucrose and 0.09% sodium azide
Q3TW96
UAP1L1
synthetic peptide corresponding to a region of mouse UAP1L1 (aa 360-409).
100 μL
Primary
Mouse
Antibody
IgG
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