UBASH3A Mouse anti-Human, Clone: OTI5B4, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF809272

Catalog No. 50-166-9384

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

TULA (T cell ubiquitin ligand, UBASH3A, ubiquitin associated and SH3 domain containing A), STS-2 or CLIP4, is a 661 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one SH3 domain and one UBA domain. Expressed at high levels in thymus, bone marrow, spleen and peripheral blood leukocytes, TULA exists as either a homodimer or a homo-oligomer that interferes with the degradation of receptor-type tyrosine kinases and promotes the accumulation of activated receptors on the cell surface. Additionally, TULA is part of an EGFR- and Cbl-containing complex that interacts with ubiquitinated proteins. The gene encoding TULA, which maps to human chromosome 21, may be involved in the pathogenesis of type I diabetes. Multiple isoforms of TULA are produced due to alternative splicing events.

Specifications

• Antigen: UBASH3A
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: UBASH3A
• Gene Alias: CLIP4, STS-2, TULA, TULA-1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 53347
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI5B4
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P57075
• Gene Symbols: UBASH3A
• Immunogen: Human recombit protein fragment corresponding to amino acids 288-549 of human UBASH3A produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b