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Invitrogen™ UBASH3A Polyclonal Antibody
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Catalog No. PIPA5101917
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100 μL
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PIPA5101917 100 μL
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Catalog No. PIPA5101917 Supplier Invitrogen™ Supplier No. PA5101917
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total UBASH3A.

TULA (T cell ubiquitin ligand, UBASH3A, ubiquitin associated and SH3 domain containing A), STS-2 or CLIP4, is a 661 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one SH3 domain and one UBA domain. Expressed at high levels in thymus, bone marrow, spleen and peripheral blood leukocytes, TULA exists as either a homodimer or a homo-oligomer that interferes with the degradation of receptor-type tyrosine kinases and promotes the accumulation of activated receptors on the cell surface. Additionally, TULA is part of an EGFR- and Cbl-containing complex that interacts with ubiquitinated proteins. The gene encoding TULA, which maps to human chromosome 21, may be involved in the pathogenesis of type I diabetes. Multiple isoforms of TULA are produced due to alternative splicing events.
TRUSTED_SUSTAINABILITY

Specifications

Antigen UBASH3A
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene UBASH3A
Gene Accession No. P57075
Gene Alias 5830413C03Rik; C330001M22; Cbl-interacting protein 4; CLIP4; STS2; Sts-2; Suppressor of T-cell receptor signaling 2; T-cell ubiquitin ligand 1; T-cell ubiquitin ligand protein; TULA; TULA1; TULA-1; Ubash3a; ubiquitin associated and SH3 domain containing A; ubiquitin associated and SH3 domain containing, A; ubiquitin-associated and SH3 domain-containing protein A
Gene Symbols UBASH3A
Host Species Rabbit
Immunogen A synthesized peptide derived from human UBASH3A(Accession P57075), corresponding to amino acid residues A313-K363.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 53347
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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