Invitrogen™ UBASH3A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5144832

Catalog No. FEPA5144832

Description

Immunogen sequence: KSVLVVRHGE RVDQIFGKAW LQQCSTPDGK YYRPDLNFPC SLPRRSRGIK DFENDPPLSS CGIFQSRIA Antigen sequence identity: Mouse 84%; Rat 83%.

TULA (T cell ubiquitin ligand, UBASH3A, ubiquitin associated and SH3 domain containing A), STS-2 or CLIP4, is a 661 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one SH3 domain and one UBA domain. Expressed at high levels in thymus, bone marrow, spleen and peripheral blood leukocytes, TULA exists as either a homodimer or a homo-oligomer that interferes with the degradation of receptor-type tyrosine kinases and promotes the accumulation of activated receptors on the cell surface. Additionally, TULA is part of an EGFR- and Cbl-containing complex that interacts with ubiquitinated proteins. The gene encoding TULA, which maps to human chromosome 21, may be involved in the pathogenesis of type I diabetes. Multiple isoforms of TULA are produced due to alternative splicing events.

Specifications

• Antigen: UBASH3A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UBASH3A
• Gene Alias: 5830413C03Rik; C330001M22; Cbl-interacting protein 4; CLIP4; STS2; Sts-2; Suppressor of T-cell receptor signaling 2; T-cell ubiquitin ligand 1; T-cell ubiquitin ligand protein; TULA; TULA1; TULA-1; Ubash3a; ubiquitin associated and SH3 domain containing A; ubiquitin associated and SH3 domain containing, A; ubiquitin-associated and SH3 domain-containing protein A
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 53347
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid
• Isotype: IgG

• Applications: Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P57075
• Gene Symbols: UBASH3A
• Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 396-464. Recombinant protein control fragment (Product #RP-109879).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Format: Liquid