Invitrogen™ UBE2D1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5119880

Catalog No. PIPA5119880

Description

Positive Control: Hela cell lysate, Jurkat cell lysate, NIH/3T3 cell lysate, rat skeletal muscle tissue lysate, mouse liver tissue lysate, rat kidney tissue, human breast tissue, mouse skeletal muscle tissue. Subcellular Location: Cytoplasm.

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.

Specifications

• Antigen: UBE2D1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UBE2D1
• Gene Alias: (E3-independent) E2 ubiquitin-conjugating enzyme D1; E2 ubiquitin-conjugating enzyme D1; E2(17)KB 1; E2(17)KB1; SFT; Stimulator of Fe transport; UBC 4/5; UBC4/5; UBC4/5 homolog; UBC5A; UBCH 5; UBCH 5A; UBCH5; UBCH5A; UBE2D1; ubiquitin; Ubiquitin carrier protein D1; ubiquitin conjugating enzyme E2 D1; ubiquitin conjugating enzyme E2D 1; ubiquitin-conjugating enzyme E2 D1; Ubiquitin-conjugating enzyme E2(17)KB 1; ubiquitin-conjugating enzyme E2-17 kDa 1; ubiquitin-conjugating enzyme E2D 1; ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast); ubiquitin-conjugating enzyme E2D 1, UBC4/5 homolog; ubiquitin-protein ligase D1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 216080, 361831, 7321
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: D3ZDK2, P51668, P61080
• Gene Symbols: UBE2D1
• Immunogen: Recombinant protein within human sft aa 1-147.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov