Invitrogen™ UBE2D3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5119881

Catalog No. PIPA5119881

Description

Positive Control: Jurkat cell lysate, 293T cell lysate, MCF-7 cell lysate, rat liver tissue lysate, mouse lung tissue lysate, SW620, mouse brain tissue. Subcellular Location: Cell membrane, Endosome membrane.

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Specifications

• Antigen: UBE2D3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UBE2D3
• Gene Alias: (E3-independent) E2 ubiquitin-conjugating enzyme D3; 1100001F19Rik; 9430029A22Rik; AA414951; E2 ubiquitin-conjugating enzyme D3; E2(17)KB 3; E2(17)KB3; eff; fb36f02; LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 D3; MGC43926; MGC5416; PAPase; Phosphoarginine phosphatase; PRO2116; similar to phosphoarginine phosphatase; UBC4/5; UBC5C; UBCH5C; Ube2d3; UBE2D3P; Ubiquitin carrier protein D3; ubiquitin conjugating enzyme E2 D3; ubiquitin conjugating enzyme E2D 3; ubiquitin-conjugating enzyme E2 D3; Ubiquitin-conjugating enzyme E2(17)KB 3; ubiquitin-conjugating enzyme E2-17 kDa 3; ubiquitin-conjugating enzyme E2D 2; ubiquitin-conjugating enzyme E2D 3; ubiquitin-conjugating enzyme E2D 3 (homologous to yeast UBC4/5); ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast); ubiquitin-protein ligase D3; Unknown (protein for MGC:127427); wu:fb36f02; zgc:56340
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 66105, 7323, 81920
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P61077, P61078, P61079
• Gene Symbols: UBE2D3
• Immunogen: Recombinant full length protein of human UBE2D3.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov