Invitrogen™ UBE3C Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110540

Catalog No. PIPA5110540

Description

Immunogen sequence: PISLEDLKSF TNYSGGYSAD HPVIKVFWRV VEGFTDEEKR KLLKFVTSCS RPPLLGFKEL YPAFCIHNGG SDLERLPTAS TCMNLLKLPE FYDETLLRSK LLYAIECAAG FELS Product note: Prior to December 2023, PA5-110540 was manufactured using a Recombinant fusion protein immunogen containing a sequence corresponding to amino acids 1-270 of human UBE3C. The affected lots are: WE3272737, WL3440149, XG3626363, 334B8A30, WH3338145, and VE2999302. Beginning in January 2024, all lots have been produced using a Recombinant fusion protein immunogen containing a sequence corresponding to amino acids 970-1083 of human UBE3C. Refer to the datasheets linked below for lot-specific immunogen information.

E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.

Specifications

• Antigen: UBE3C
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UBE3C
• Gene Alias: AI853514; HectH2; HECT-type ubiquitin transferase E3C; KIAA0010; KIAA10; mKIAA0010; RGD1559986; Ube3c; ubiquitin protein ligase E3C; ubiquitin-protein isopeptide ligase (E3); ubiquitin-protein ligase E3C
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9690
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 0.81 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q15386
• Gene Symbols: UBE3C
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 970-1083 of human UBE3C (NP_0554862).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG