Invitrogen™ UBE4A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120865

Catalog No. PIPA5120865

Description

Positive test controls include: MCF7, HepG2, 293T, Mouse kidney, Mouse pancreas, Mouse liver. The target is usually found in the following locations: Cytoplasm. Immunogen sequence: FLLDEAIQYL SKIKIQQIEK DRGEWDSLTP EARREKEAGL QMFGQLARFH NIMSNETIGT LAFLTSEIKS LFVHPFLAER IISMLNYFLQ HLVGPKMGAL KVKDFSEFDF KPQQLVSDIC TIYLNLGDEE NFCATVPKDG RSYSPTLFAQ TVRVLKKINK PGNMIMAFSN LAERIKSLAD LQQQEEETYA DACDEFLDPI MSTLMCDPVV LPSSRVTVDR STIARHLLSD QTDPFNRSPL TMDQIRPNTE LKEKIQRWLA ERKQQKEQLE.

Ubiquitination requires a ubiquitin-activating enzyme, a ubiquitin-conjugating enzyme, and usually a substrate-specific ubiquitin-protein ligase. Multiubiquitination needs a fourth factor, to bind to the ubiquitin moieties of preformed conjugates and catalyze ubiquitin chain assembly in conjunction with the first three proteins. Human protein KIAA0126, with a predicted 1,073 amino acid residues, is a member of the novel protein family defined by ubiquitination conjugation factor E4. In yeast, E4 activity is linked to cell survival under stress conditions, indicating that eucaryotes use E4-dependent proteolysis pathways for multiple cellular functions.

Specifications

• Antigen: UBE4A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ube4a
• Gene Alias: 4732444G18Rik; 9930123J21Rik; Ab2-232; E4; KIAA0126; RING-type E3 ubiquitin transferase E4 A; UBE4A; Ubiquitin conjugation factor E4 A; ubiquitination factor E4A; ubiquitination factor E4A (UFD2 homolog, yeast); ubiquitination factor E4A, UFD2 homolog; UBOX2; UFD2; UFD2b
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 140630, 315608, 9354
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.75 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: E9Q735, Q14139, Q6P7A2
• Gene Symbols: Ube4a
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 797-1066 of human UBE4A (NP_001191006.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG