Invitrogen™ UBE4B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA522023

Catalog No. PIPA522023

Description

Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji. Predicted reactivity: Mouse (99%), Rat (98%), Zebrafish (90%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE4B represents an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. UBE4B also the strongest candidate among the neuroblastoma tumor suppressors.

Specifications

• Antigen: UBE4B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UBE4B
• Gene Alias: 4930551I19Rik; 4933406G05Rik; AU014668; D4Bwg0973e; E4; HDNB1; homologous to yeast UFD2; homozygously deleted in neuroblastoma 1; homozygously deleted in neuroblastoma-1; KIAA0684; mKIAA0684; RING-type E3 ubiquitin transferase E4 B; Ube4b; Ubiquitin conjugation factor E4 B; ubiquitin fusion degradation protein 2; ubiquitination factor E4B; ubiquitination factor E4B (homologous to yeast UFD2); ubiquitination factor E4B (UFD2 homolog, yeast); ubiquitination factor E4B, UFD2 homolog; ubiquitin-fusion degradation protein 2; UBOX3; UFD2; Ufd2a; UFD2A-III/UBE4B-III splice isoform; Ufd2p
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10277
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: O95155
• Gene Symbols: UBE4B
• Immunogen: Recombinant fragment corresponding to a region within amino acids 869 and 1179 of UBE4B (Uniprot ID#O95155).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG