Invitrogen™ Ubinuclein 2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA554071

Catalog No. PIPA554071

Description

Immunogen sequence: SVTNQNVTPF GMLGGLVPVT MPFQFPLEIF GFGTDTAGVT TTSGSTSAAF HHSLTQNLLK GLQPGGAQHA ATLSHSPLPA HLQQAFHDGG QSKGDTKLPR KS Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 87%.

Ubinuclein 1 (UBN1) is a ubiquitously expressed evolutionarily conserved protein which binds to proliferation-promoting genes that are repressed by formation of senescence-associated heterochromatin foci (SAHF). Ubinuclein 1 associates with various transcription factors and with histone methyltransferase activity, is indispensable for SAHF formation and appears to be a regulator of senescence. Although in most cells ubinuclein is localized to the nucleus, in cells forming tight junctions it is recruited to the cell adhesion complexes, dependently on the cell density.

Specifications

• Antigen: Ubinuclein 2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UBN2
• Gene Alias: 2900060J04Rik; 6030408G03Rik; BC060116; D130059P03Rik; Kiaa2030; mKIAA2030; ubinuclein 1; ubinuclein 2; ubinuclein-2; UBN1; UBN2; VT; VT4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 254048
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6ZU65
• Gene Symbols: UBN2
• Immunogen: Recombinant protein corresponding to Human Ubinuclein 1/2. Recombinant protein control fragment (Product #RP-92771).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov