Invitrogen™ Ubinuclein 1/2 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA537942

Catalog No. PIPA537942

Description

This antibody is predicted to react with mouse, rat, dog, pig, cow and zebrafish based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.

Ubinuclein 1 (UBN1) is a ubiquitously expressed evolutionarily conserved protein which binds to proliferation-promoting genes that are repressed by formation of senescence-associated heterochromatin foci (SAHF). Ubinuclein 1 associates with various transcription factors and with histone methyltransferase activity, is indispensable for SAHF formation and appears to be a regulator of senescence. Although in most cells ubinuclein is localized to the nucleus, in cells forming tight junctions it is recruited to the cell adhesion complexes, dependently on the cell density.

Specifications

• Antigen: Ubinuclein 1/2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UBN2
• Gene Alias: HIRA-binding protein; KIAA2030; Protein VT4; ubinuclein 1; ubinuclein 2; ubinuclein-1; Ubinuclein-2; ubiquitously expressed nuclear protein; UBN1; UBN2; VT; VT4
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 254048, 29855
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q6ZU65, Q9NPG3
• Gene Symbols: UBN1, UBN2
• Immunogen: Peptide with sequence C-DNSEAYDELVPASLT, from the internal region of UBN1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov