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  6. Invitrogen™ Ubiquilin 4 Recombinant Rabbit Monoclonal Antibody (BLR145J)

Invitrogen™ Ubiquilin 4 Recombinant Rabbit Monoclonal Antibody (BLR145J)
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Catalog No. PIMA544477
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100 μL
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PIMA544477 100 μL
PIMA544478 10 μL
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Catalog No. PIMA544477 Supplier Invitrogen™ Supplier No. MA544477
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Description

Rabbit Recombinant Monoclonal Antibody

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

The ubiquitin-proteosome pathway of protein degradation is one of the mechanisms that ensure the proper level of cellular proteins. The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain containing protein family is thought to be involved in proteosomal degradation. One such protein is CIP75, also known as ubiquilin-4, interacts with a number of proteins such as Ataxin-1 and Connexin-43, resulting in an increased rate of turnover of these proteins. Overexpression CIP75 led to a significant reduction of Connexin-43 half-life, with the opposite being observed in siRNA knockdown experiments. CIP75 contains an N-terminal UbL domain which is thought to interact with proteins of the 26S proteosome complex and a C-terminal UBA domain which appears to mediate its interaction with Connexin-75. At least three isoforms of CIP75 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Ubiquilin 4
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone BLR145J
Concentration 50 μg/mL
Conjugate Unconjugated
Formulation BBS with 0.1% BSA and 0.09% sodium azide; pH 8.2
Gene UBQLN4
Gene Accession No. Q9NRR5
Gene Alias A1u; A1Up; AI663987; Ataxin-1 interacting ubiquitin-like protein; ataxin-1 ubiquitin-like interacting protein; ataxin-1 ubiquitin-like-interacting protein A1U; C1orf6; CIP75; Connexin43-interacting protein of 75 kDa; RGD1308273; RP11-336K24.8; UBIN; ubiquilin 4; ubiquilin-4; UBQLN4
Gene Symbols UBQLN4
Host Species Rabbit
Immunogen Recombinant protein representing Human Ubiquilin-4 (residues 2-601).
Purification Method Purified
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 56893
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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