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Invitrogen™ Ubiquitin B Monoclonal Antibody (3C12)
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Catalog No. PIMA517196
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100 μg
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Catalog No. Quantity
PIMA517196 100 μg
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Catalog No. PIMA517196 Supplier Invitrogen™ Supplier No. MA517196
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Description

Mouse Monoclonal Antibody

MA5-17196 targets UBB in FACS, indirect ELISA, and WB applications and shows reactivity with Human samples. The MA5-17196 immunogen is purified recombinant fragment of human UBB expressed in E. Coli. MA5-17196 detects UBB which has a predicted molecular weight of approximately 26kDa.

Ubiquitin is a highly conserved protein of about 8.5 kDa molecular weight, which has an ATP dependent role in the targeting of proteins for proteolytic degradation. To perform this function, the protein to be degraded is first covalently attached to the C terminus of ubiquitin, and the ubiquitinated complex is then recognized by a complex of degradative enzymes. Interestingly, ubiquitin also becomes covalently bonded to many types of pathological inclusions, which appear to be resistant to normal degradation. Therefore, ubiquitin antibodies are very useful for studies of these inclusions. For example, the neurofibrillary tangles and paired helical filaments diagnostic of Alzheimer's disease, Lewy bodies seen in Parkinson's disease, and Pick bodies found in Pick's disease are all heavily ubiquitinated and can be readily visualized with ubiquitin antibodies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Ubiquitin B
Applications ELISA, Flow Cytometry, Western Blot
Classification Monoclonal
Clone 3C12
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene UBB
Gene Accession No. P0CG47, P0CG49
Gene Alias AL033289; epididymis secretory protein Li 50; HEL-S-50; HUBCEP52; im:6892314; im:6892314 protein; MGC127041; polyubiquitin; polyubiquitin B; polyubiquitin-B; RPL40; Rps27a; si:ch211-202a12.3; Uba52; Ubb; Ubb2; UBC; Ubi-p63E; Ubiquitin; ubiquitin B; ubiquitin C; Ubiquitin-related; zgc:172187; zUBC
Gene Symbols UBB
Host Species Mouse
Immunogen Purified recombinant fragment of human UBB expressed in E. Coli.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22187, 7314
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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