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Invitrogen™ Ubiquitin B Polyclonal Antibody
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Catalog No. PIPA570602
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100 μL
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PIPA570602 100 μL
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Catalog No. PIPA570602 Supplier Invitrogen™ Supplier No. PA570602
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Description

Rabbit Polyclonal Antibody

This target displays homology in the following species: Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Yeast: 100%; Zebrafish: 100%.

Ubiquitin is a highly conserved protein of about 8.5 kDa molecular weight, which has an ATP dependent role in the targeting of proteins for proteolytic degradation. To perform this function, the protein to be degraded is first covalently attached to the C terminus of ubiquitin, and the ubiquitinated complex is then recognized by a complex of degradative enzymes. Interestingly, ubiquitin also becomes covalently bonded to many types of pathological inclusions, which appear to be resistant to normal degradation. Therefore, ubiquitin antibodies are very useful for studies of these inclusions. For example, the neurofibrillary tangles and paired helical filaments diagnostic of Alzheimer's disease, Lewy bodies seen in Parkinson's disease, and Pick bodies found in Pick's disease are all heavily ubiquitinated and can be readily visualized with ubiquitin antibodies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Ubiquitin B
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene UBB
Gene Accession No. P0CG47, P0CG49
Gene Alias AL033289; epididymis secretory protein Li 50; HEL-S-50; HUBCEP52; im:6892314; im:6892314 protein; MGC127041; polyubiquitin; polyubiquitin B; polyubiquitin-B; RPL40; Rps27a; si:ch211-202a12.3; Uba52; Ubb; Ubb2; UBC; Ubi-p63E; Ubiquitin; ubiquitin B; ubiquitin C; Ubiquitin-related; zgc:172187; zUBC
Gene Symbols UBB
Host Species Rabbit
Immunogen synthetic peptide directed towards the middle region of human Ubiquitin B.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22187, 7314
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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