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Invitrogen™ Ubiquitin C Polyclonal Antibody
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Catalog No. PIPA5120862
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PIPA5120862 100 μL
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Catalog No. PIPA5120862 Supplier Invitrogen™ Supplier No. PA5120862
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Description

Rabbit Polyclonal Antibody

Positive test controls include: 293T, BT-474, HepG2, U-251MG, A-549, Mouse testis, Mouse liver, Rat testis, Rat brain. The target is usually found in the following locations: Cytoplasm, Nucleus. Immunogen sequence: MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGGMQIF VKTLTGKTIT LEVEPSDTIE.

This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Ubiquitin C
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.16 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene UBC
Gene Accession No. P0CG48, P0CG50, Q63429
Gene Alias 2700054O04Rik; AI194771; HMG20; polyubiquitin C; polyubiquitin-C; Rps27a; TI-225; Uba52; Ubb; Ubc; Ubiquitin; ubiquitin C; Ubiquitin-related; Ubiquitin-related 1; Ubiquitin-related 2
Gene Symbols UBC
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-100 of human UBC (NP_066289.3).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22190, 50522, 7316
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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