Invitrogen™ Ubiquitin C Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA576144

Catalog No. PIPA576144

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.

Specifications

• Antigen: Ubiquitin C
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UBC
• Gene Alias: 2700054O04Rik; AI194771; HMG20; polyubiquitin C; polyubiquitin-C; Rps27a; TI-225; Uba52; Ubb; Ubc; Ubiquitin; ubiquitin C; Ubiquitin-related; Ubiquitin-related 1; Ubiquitin-related 2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22190, 50522, 7316
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P0CG48, P0CG50, Q63429
• Gene Symbols: UBC
• Immunogen: Synthetic peptide of human Poly-Ubiquitin.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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