UBR1 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-5191	Proteintech Group Inc 260691AP150UL	150 μL

Description

ELK1 is a component of the ternary complex that binds the serum response element (SRE) and mediates gene activity in response to serum and growth factors. ELK1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus. Phosphorylation at these sites, particularly Ser383, is critical for transcriptional activation by ELK1. ELK1 appears to be a direct target of activated MAP kinase. Biochemical studies indicate that ELK1 is a good substrate for MAP kinase, the kinetics of ELK1 phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block ELK1 activation in vivo. ELK1 is a nuclear target for the ras-raf-MAPK signaling cascade. Alternatively spliced transcript variants encoding the same protein have been found for ELK1.

Specifications

• Antigen: UBR1
• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: Q8IWV7
• Gene ID (Entrez): 197131
• Immunogen: UBR1 Fusion Protein Ag22076
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: UBR1

• Concentration: 0.37 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: JBS, N recognin 1, UBR1
• Gene Symbols: UBR1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody