UCH-L1/PGP9.5 Antibody (UCHL1/775) - IHC-Prediluted, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP248315

Catalog No. NBP248315

Description

UCH-L1/PGP9.5 Monoclonal specifically detects UCH-L1/PGP9.5 in Human, Rat samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: UCH-L1/PGP9.5
• Classification: Monoclonal
• Conjugate: Unconjugated
• Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
• Gene Symbols: UCHL1
• Immunogen: Recombinant human UCH-L1/PGP9.5 protein (Uniprot: P09936)
• Quantity: 7 mL
• Research Discipline: Alzheimers Research, Cellular Markers, Neurodegeneration, Neuronal Cell Markers, Neuroscience, Neurotransmission
• Gene ID (Entrez): 7345
• Target Species: Human, Rat
• Form: Purified

• Applications: Immunohistochemistry, Immunohistochemistry (Paraffin)
• Clone: UCHL1/775
• Dilution: Immunohistochemistry, Immunohistochemistry-Paraffin
• Gene Alias: EC 3.4.19.12, EC 6.-, Neuron cytoplasmic protein 9.5, PARK5, PGP 9.5, PGP9.5, PGP9.5Uch-L1, PGP95, ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase), ubiquitin carboxyl-terminal hydrolase isozyme L1, ubiquitin C-terminal hydrolase, Ubiquitin thioesterase L1, UCHL1, UCH-L1
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: This MAb reacts with a protein of 20-30kDa, identified as PGP9.5, also known as ubiquitin carboxyl-terminal hydrolase-1 (UchL1). Initially, PGP9.5 expression in normal tissues was reported in neurons and neuroendocrine cells but later it was found in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts. Furthermore, immunostaining for PGP9.5 has been shown in a wide variety of mesenchymal neoplasms as well. A mutation in PGP9.5 gene is believed to cause a form of Parkinson's disease.
• Content And Storage: Store at 4C.
• Isotype: IgG1 κ