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Invitrogen™ UCH37 Monoclonal Antibody (854CT5.5.6)
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Catalog No. PIMA518114
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400 μL
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Catalog No. Quantity
PIMA518114 400 μL
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Catalog No. PIMA518114 Supplier Invitrogen™ Supplier No. MA518114
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Description

Mouse Monoclonal Antibody

UCH37 Monoclonal Antibody for Western Blot

UCH-L5 (ubiquitin carboxyl-terminal hydrolase isozyme L5), also known as UCH37, is a 329 amino acid protein that functions to edit polyubiquinated protein substrates. Since UCH-L5 has the potential to rescue ubiquinated proteins, including oncogenic proteins, from proteasomal degradation, it is likely that deregulation of UCH-L5 may affect tumor growth. Through associations with Smad7, UHC-L5 can dramatically upregulate TGFβ-dependent gene expression by de-ubiquinating and stabilizing TGFβ RI. Also, since overexpression of UCH-L5 and other deubiquitinating enzymes has been observed in many cancer cell lines, inhibition of these proteins may be of some interest in designing therapies for cancer treatment. There are four isoforms of UCH-L5 that exist as a result of alternative splicing events.
TRUSTED_SUSTAINABILITY

Specifications

Antigen UCH37
Applications Western Blot
Classification Monoclonal
Clone 854CT5.5.6
Concentration 0.37 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene UCHL5
Gene Accession No. Q9Y5K5
Gene Alias 5830413B11Rik; AD-019; CGI-70; INO80 complex subunit R; INO80R; ubiquitin carboxyl-terminal esterase L5; ubiquitin carboxyl-terminal hydrolase isozyme L5; ubiquitin carboxyl-terminal hydrolase L5; ubiquitin C-terminal hydrolase 37; ubiquitin C-terminal hydrolase L5; ubiquitin C-terminal hydrolase UCH37; ubiquitin thioesterase L5; UCH37; Uchl5; UCH-L5
Gene Symbols UCHL5
Host Species Mouse
Immunogen Purified His-tagged UCH37 protein.
Purification Method Protein G
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51377
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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