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Invitrogen™ UCH37 Polyclonal Antibody
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Catalog No. PIPA585693
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100 μL
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PIPA585693 100 μL
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Catalog No. PIPA585693 Supplier Invitrogen™ Supplier No. PA585693
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Description

Rabbit Polyclonal Antibody

Keep as concentrated solution. Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (83%), Xenopus laevis (90%), Pig (98%), Chicken (89%), Bovine (98%). Positive Control: 293T. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

UCH-L5 (ubiquitin carboxyl-terminal hydrolase isozyme L5), also known as UCH37, is a 329 amino acid protein that functions to edit polyubiquinated protein substrates. Since UCH-L5 has the potential to rescue ubiquinated proteins, including oncogenic proteins, from proteasomal degradation, it is likely that deregulation of UCH-L5 may affect tumor growth. Through associations with Smad7, UHC-L5 can dramatically upregulate TGFβ-dependent gene expression by de-ubiquinating and stabilizing TGFβ RI. Also, since overexpression of UCH-L5 and other deubiquitinating enzymes has been observed in many cancer cell lines, inhibition of these proteins may be of some interest in designing therapies for cancer treatment. There are four isoforms of UCH-L5 that exist as a result of alternative splicing events.
TRUSTED_SUSTAINABILITY

Specifications

Antigen UCH37
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1.48 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene UCHL5
Gene Accession No. Q9Y5K5
Gene Alias 5830413B11Rik; AD-019; CGI-70; INO80 complex subunit R; INO80R; ubiquitin carboxyl-terminal esterase L5; ubiquitin carboxyl-terminal hydrolase isozyme L5; ubiquitin carboxyl-terminal hydrolase L5; ubiquitin C-terminal hydrolase 37; ubiquitin C-terminal hydrolase L5; ubiquitin C-terminal hydrolase UCH37; ubiquitin thioesterase L5; UCH37; Uchl5; UCH-L5
Gene Symbols UCHL5
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the N-terminus region of human UCHL5. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51377
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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