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UCH37 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501566879
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50-156-6879 10 μL
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Catalog No. 50-156-6879 Supplier Bethyl Laboratories, Inc Supplier No. A304101AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Mouse, Bovine and Pig

Covalent attachment of the C-terminus of ubiquitin to cellular proteins plays a role in a variety of cellular processes. Ubiquitin C-terminal hydrolysis is catalyzed by deubiquitinating (DUB) enzymes and is necessary for several functions, including liberation of monomeric ubiquitin from the precursors encoded by ubiquitin genes and recycling of ubiquitin monomers. There are 2 distinct families of DUBs, ubiquitin-specific proteases (UBPs) and ubiquitin C-terminal hydrolases (UCHs). Mayer and Wilkinson (1989) identified 4 distinct UCH activities from bovine thymus. All 4 were thiol proteases and had high-affinity binding sites for ubiquitin. Wilkinson et al. (1989) purified the predomit isozyme, UCHL3, and raised antibodies against it. By screening a human B-cell expression library with the antibodies, the authors isolated cDNAs encoding human UCHL3. Sequence comparisons revealed that the sequence of the predicted 230-amino acid human UCHL3 protein is 54% identical to that of UCHL1.

Specifications

Antigen UCH37
Applications Immunoprecipitation
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene UCHL5
Gene Accession No. Q9Y5K5
Gene Alias Ubiquitin carboxyl-terminal hydrolase isozyme L5; Ubiquitin thiolesterase L5; Ubiquitin C-terminal hydrolase UCH37; CGI-70; AD-019
Gene Symbols UCHL5
Host Species Rabbit
Immunogen Between 279 and 329
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51377
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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