UCMA Rabbit anti-Human, Polyclonal, Proteintech

Catalog No.	Quantity
50-173-4935	150 μL

Catalog No. 50-173-4935 Supplier Proteintech Group Inc Supplier No. 255031AP150UL

Description

Rabbit Polyclonal Antibody

UCMA is a secreted cartilage-specific protein that was discovered in a screen for differentially expressed genes in retinoic acid-treated mouse chondrocytes. It was also identified in a human chondrocyte EST screen for candidate genes of skeletal dysplasias. UCMA expression is thought to parallel that of collagen II with its expression decreasing with maturation chrondrocytes mature. UCMA is processed by a furin-like protease into two fragments, an amino-terminal fragment and a carboxy-terminal fragment (UCMA-C). Application of recombit UCMA-C to primary osteoblasts, mesenchymal stem cells, and MC3T3-E1 pre-osteoblasts interferes with their osteogenic differentiation, but does not affect expression of chondrocyte-specific genes or chondrocyte proliferation, suggesting that UCMA may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells. At least two isoforms of UCMA are known to exist.

Specifications

• Antigen: UCMA
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.34 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene: UCMA
• Gene Accession No.: Q8WVF2
• Gene Alias: C10orf49, Gla rich protein, GRP, UCMA, Ucma C
• Gene Symbols: UCMA
• Host Species: Rabbit
• Immunogen: UCMA Fusion Protein Ag21985
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 221044
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG