Invitrogen™ UCP1 Monoclonal Antibody (GT3111)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA531534

Catalog No. PIMA531534

Description

Keep as concentrated solution. Predicted reactivity: Mouse (80%), Rat (80%), Rabbit (86%), Sheep (83%), Bovine (84%). Positive Control: mouse brown adipose. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Mitochondrial uncoupling proteins are members of the family of mitochondrial anion carrier proteins. UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.

Specifications

• Antigen: UCP1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: P12242, P25874
• Gene Symbols: Ucp1
• Immunogen: Recombinant protein encompassing a sequence within the center region of human UCP1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: GT3111
• Conjugate: Unconjugated
• Gene: Ucp1
• Gene Alias: AI385626; HGNC:12517; mitochondrial brown fat uncoupling protein 1; SLC25A7; solute carrier family 25 member 7; Thermogenin; Ucp; UCP 1; Ucp1; Ucpa; uncoupling protein; uncoupling protein 1; uncoupling protein 1 (mitochondrial, proton carrier); uncoupling protein 1, mitochondrial; uncoupling protein, mitochondrial; Uncp; unnamed protein product
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 22227, 7350
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid