Invitrogen™ UCP3 Polyclonal Antibody

Catalog No.	Quantity
PA124895	100 μL

Catalog No. PA124895 Supplier Invitrogen™ Supplier No. PA124895

Description

Rabbit Polyclonal Antibody

Recommended positive controls: human and mouse skeletal muscle, mitochondrial extract of rat brown adipose tissue. The corresponding sequence in rat and mouse UCP3 differ by 4 and 3 amino acids respectively. This antibody exhibits no cross reactivity with UCP1 or UCP2. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The uncoupling protein UCP1 (formerly designated UCP) is an integral membrane protein unique to brown adipose tissue mitochondria. UCP1 forms a dimer that acts as a proton channel, which can uncouple oxidative phosphorylation by dissipating the electrochemical potential across the inner mitochondrial membrane. This process induces heat production in brown adipose tissue and is involved in regulation of body temperature and glucose metabolism. UCP2 is a structurally related protein that also uncouples mitochondrial respiration. It is more widely expressed in human and mouse tissues, including white adipose tissue and muscle, than is UCP1. UCP2 is thought to play a role in body weight regulation. An additional UCP family member, UCP3, is highly muscle specific and is possibly involved in the uncoupling of oxidative phosphorylation in skeletal muscle.

Specifications

• Antigen: UCP3
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA and 15mM sodium azide; pH 7.4
• Gene: Ucp3
• Gene Accession No.: P55916, P56499, P56501
• Gene Alias: AI645527; mitochondrial uncoupling protein 3; Slc25a9; solute carrier family 25 member 9; UCP 3; UCP3; UCP-3; uncoupling protein; uncoupling protein 3; uncoupling protein 3 (mitochondrial, proton carrier); uncoupling protein 3, mitochondrial
• Gene Symbols: Ucp3
• Host Species: Rabbit
• Immunogen: Synthetic peptide corresponding to human UCP-3 sequence (amino acids 254-267) with N-terminal lysine added, conjugated to KLH.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 22229, 25708, 7352
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG