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Invitrogen™ UGGT1 Polyclonal Antibody
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Catalog No. PIPA553281
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100 μL
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PIPA553281 100 μL
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Catalog No. PIPA553281 Supplier Invitrogen™ Supplier No. PA553281
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KVKVEHVVSV LEKKYPYVEV NSILGIDSAY DRNRKEARGY YEQTGVGPLP VVLFNGMPFE REQLDPDELE TITMHKILET TTFFQRAVYL GELPHDQDVV EYIMNQPNVV PRINSRILTA ERDYLDLTAS NNFFVDDYA Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 95%.

UDP-glucose:glycoprotein glucosyltransferase (UGGT) is a 170 kDa lumenal endoplasmic reticulum (ER) resident protein that catalyzes monoglucosylation of high mannose oligosaccharides. UGGT catalyzes the transfer of glucose from UDP-glucose to Man7-9GlcNAc2-moiety of unfolded glycoproteins in a Ca2+ dependent reaction. UGGT binds unfolded glycoprotein via two elements on its substrate: a N-acetylglucosamine unit on the oligosaccharide and hydrophobic amino acids that are exposed in the denatured conformation. It is postulated that UGGT serves as a sensor that is able to distinguish between folded and denatured protein in the ER.
TRUSTED_SUSTAINABILITY

Specifications

Antigen UGGT1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Uggt1
Gene Accession No. Q6P5E4, Q9JLA3, Q9NYU2
Gene Alias 0910001L17Rik; A930007H10Rik; AA589501; AI414429; AI448372; C820010P03Rik; Gt; HUGT1; RUGT; rUGT1; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose ceramide glucosyltransferase-like 1; UDP-glucose glycoprotein glucosyltransferase 1; UDP-glucose glycoprotein: glucosyltransferase UGGT; UDP-glucose:glycoprotein glucosyltransferase; UDP-glucose:glycoprotein glucosyltransferase 1; UGCGL1; Uggt; Uggt1; Ugt1; Ugtr
Gene Symbols Uggt1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human UGGT1.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 171129, 320011, 56886
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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