Invitrogen™ UGGT1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA592309

Catalog No. PIPA592309

Description

Immunogen sequence: PNNMIHQVPI KSLPQEWLWC ETWCDDASKK RAKTIDLCNN PMTKEPKLEA AVRIVPEWQD YDQEIKQLQI RFQKEKETGA LYKEKTKEPS REGPQKREEL; Positive Samples: SH-SY5Y, 293T, HepG2, HL-60, HT-1080, Mouse liver, Mouse kidney, Rat liver, Rat brain; Cellular Location: Endoplasmic reticulum lumen, Endoplasmic reticulum-Golgi intermediate compartment.

UDP-glucose:glycoprotein glucosyltransferase (UGGT) is a 170 kDa lumenal endoplasmic reticulum (ER) resident protein that catalyzes monoglucosylation of high mannose oligosaccharides. UGGT catalyzes the transfer of glucose from UDP-glucose to Man7-9GlcNAc2-moiety of unfolded glycoproteins in a Ca2+ dependent reaction. UGGT binds unfolded glycoprotein via two elements on its substrate: a N-acetylglucosamine unit on the oligosaccharide and hydrophobic amino acids that are exposed in the denatured conformation. It is postulated that UGGT serves as a sensor that is able to distinguish between folded and denatured protein in the ER.

Specifications

• Antigen: UGGT1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Uggt1
• Gene Alias: 0910001L17Rik; A930007H10Rik; AA589501; AI414429; AI448372; C820010P03Rik; Gt; HUGT1; RUGT; rUGT1; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose ceramide glucosyltransferase-like 1; UDP-glucose glycoprotein glucosyltransferase 1; UDP-glucose glycoprotein: glucosyltransferase UGGT; UDP-glucose:glycoprotein glucosyltransferase; UDP-glucose:glycoprotein glucosyltransferase 1; UGCGL1; Uggt; Uggt1; Ugt1; Ugtr
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 171129, 320011, 56886
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.96 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q6P5E4, Q9JLA3, Q9NYU2
• Gene Symbols: Uggt1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1456-1555 of human UGGT1 (NP_0645051).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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