Invitrogen™ UGGT1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5145406

Catalog No. FEPA5145406

Description

UDP-glucose:glycoprotein glucosyltransferase (UGGT) is a 170 kDa lumenal endoplasmic reticulum (ER) resident protein that catalyzes monoglucosylation of high mannose oligosaccharides. UGGT catalyzes the transfer of glucose from UDP-glucose to Man7-9GlcNAc2-moiety of unfolded glycoproteins in a Ca2+ dependent reaction. UGGT binds unfolded glycoprotein via two elements on its substrate: a N-acetylglucosamine unit on the oligosaccharide and hydrophobic amino acids that are exposed in the denatured conformation. It is postulated that UGGT serves as a sensor that is able to distinguish between folded and denatured protein in the ER.

Specifications

• Antigen: UGGT1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Uggt1
• Gene Alias: 0910001L17Rik; A930007H10Rik; AA589501; AI414429; AI448372; C820010P03Rik; Gt; HUGT1; RUGT; rUGT1; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose ceramide glucosyltransferase-like 1; UDP-glucose glycoprotein glucosyltransferase 1; UDP-glucose glycoprotein: glucosyltransferase UGGT; UDP-glucose:glycoprotein glucosyltransferase; UDP-glucose:glycoprotein glucosyltransferase 1; UGCGL1; Uggt; Uggt1; Ugt1; Ugtr
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 100155117, 56886
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% Proclin 300; pH 7.4
• Gene Accession No.: Q9NYU2
• Gene Symbols: Uggt1
• Immunogen: Recombinant Human UGGT1 protein, Leu1221-Leu1536 (Accession #Q9NYU2).
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human, Pig
• Product Type: Antibody
• Isotype: IgG