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Invitrogen™ UGT1A1 Polyclonal Antibody
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Catalog No. PIPA542553
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100 μL
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PIPA542553 100 μL
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Catalog No. PIPA542553 Supplier Invitrogen™ Supplier No. PA542553
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Description

Rabbit Polyclonal Antibody

Peptide sequence: DGSHWLSMLG AIQQLQQRGH EIVVLAPDAS LYIRDGAFYT LKTYPVPFQR Sequence homology: Horse: 86%; Human: 100%; Mouse: 79%; Rat: 82%.

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen UGT1A1
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene UGT1A1
Gene Accession No. P22309
Gene Alias B1; BILIQTL1; bilirubin UDP-glucuronosyltranserase; bilirubin UDP-glucuronosyltransferase 1-1; bilirubin UDP-glucuronosyltransferase isozyme 1; bilirubin-specific UDPGT isozyme 1; EC 2.4.1.17; GNT1; HUG BR1; HUGBR1; hUG-BR1; UDP glucuronosyltransferase 1 family, polypeptide A1; UDP glucuronosyltransferase family 1 member A1; UDP glycosyltransferase 1 family, polypeptide A1; UDP-glucuronosyltransferase 1 family member 1; UDP-glucuronosyltransferase 1 family, member 1; UDP-glucuronosyltransferase 1 family, polypeptide A1; UDP-glucuronosyltransferase 1-1; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1A1; UDPGT; UDPGT 1-1; Udpgt-1a; UGT 1A; UGT1; UGT1 01; UGT1*1; UGT1.1; UGT1-01; UGT1A; UGT-1A; UGT1A01; UGT1A1; UGTBR1
Gene Symbols UGT1A1
Host Species Rabbit
Immunogen Synthetic peptide directed towards the N-terminal of human UGT1A1 (aa 36-85).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54658
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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